Publications
(36) Voltage-gated electrosynthesis enables selective hydrotrifluoromethylation of olefins
Eva Maria Alvarez,* Jinxiao Li, and Christian A. Malapit*
Angew. Chem. Int. Ed. 2024, Accepted article
(35) Waste-derived low potential anolyte for energy-dense non-aqueous redox-flow battery
Emily Mahoney, Maxime Boudjelel, Henry Shavel, Matthew Krzyaniak, Michael Wasielewski, and Christian A. Malapit*
Manuscript under revision.
(34) Electrochemical non-directed arene C–H amination (invited review)
Griffin Stewart, Chris Rapala, and Christian A. Malapit*
ChemCatChem 2024, e202400867
(33) Electrochemical generation of aryl radicals from organoboron reagents enabled by pulsed electrosynthesis
Maxime Boudjelel, Jessica Zhong, Lorenzo Ballerini, Ian Vanswearingen, Rossul Aldhufari, and Christian A. Malapit*
Angew. Chem. Int. Ed. 2024, 63, e202406203
(32) Site-selective electrochemical arene C–H amination
Eva Maria Alvarez, Griffin Stewart, Mohammed Ullah, Remy Lallise, Osvaldo Gutierez, and Christian A. Malapit*
J. Am. Chem. Soc. 2024, 146, 3591–3597.
[Paper link] | [Supporting information]
Most read paper in JACS for the months of February and March.
Highlighted in Synfacts; Trauner, D., Etling, C. Synfacts 2024, 20, 0422.
Featured in Items of Interest to Process R&D Chemists
Org. Process Res. Dev. 2024, 28, 805 [Link]
Highlighted in ChemistryViews [Link]
Highlighted in Synthesis Workshop Youtube lecture. [Video] [Español]
Invited for Organic Synthesis method article
Invited for Conceptual Review in ChemCatChem [Concept]
(31) Homogeneous catalysis for the conversion of CO2, CO, CH3OH, and CH4 to C2+ chemicals via C–C bond formation
(30) Advances on the merger of electrochemistry and transition metal catalysis for organic synthesis
Christian A. Malapit, Matthew B. Prater, Jaime R. Cabrera-Pardo, Min Li, Tammy D. Pham, Timothy Patrick McFadden, Skylar Blank, and Shelley D. Minteer
Chemical Reviews 2022, 122, 3180
[review]
(29) Cobalt-electrocatalytic hydrogen atom transfer for functionalization of unsaturated C–C bonds
Samer Gnaim, Adriano Bauer, Hai-Jun Zhang, Longrui Chen, Cara Gannet, Christian A. Malapit, David Hill, David Vogt, Tianhau Tang, Ryan Daley, Wei Hao, Wesley D. Beck, Hector Abruna, Donna Blackmond, Shelley D. Minteer, Sarah Reisman, Matthew S. Sigman, and Phil S. Baran
Nature 2022, 605, 687–695
(28) Electrochemical cobalt-catalyzed selective carboxylation of benzyl halides with CO2 enabled by low-coordinate cobalt electrocatalysts
Christian A. Malapit, Mayank Tanwar, Andrew D. Pendergast, Sagar Udyavara, Wesley D. Beck, Ryan Edison Smith, Selma Kadic, Tommy Primo, Ding B. Wu, Tanner Stone, Henry S. White, Matthew Neurock, Matthew S. Sigman,and Shelley D. Minteer
ChemRxiv, DOI: 10.33774/chemrxiv-2021-thftp
[paper]
(26) Decarbonylative fluoroalkylation at palladium(II): from fundamental organometallic studies to catalysis
Naish Lalloo, Christian A. Malapit, S. Maryamdokht Taimoory, Conor E. Brigham, and Melanie S. Sanford
J. Am. Chem. Soc. 2021, 143, 18617
(25) N-Ammonium ylide mediators for selective electrochemical C–H oxidation
Masato Saito, Yu Kawamata, Michael Meanwell, Rafael Navratil, Debora Chiodi, Ethan Carlson, Pengfei Hu, Longrui Chen, Sagar Udyavara, Cian Kingston, Mayank Tanwar, Sameer Tyagi, Bruce P. McKillican, Moses G. Gichinga, Michael A. Schmidt, Martin D. Eastgate, Massimiliano Lamberto, Chi He, Tianhua Tang, Christian A. Malapit, Matthew S. Sigman, Shelley D. Minteer, Matthew Neurock, and Phil S. Baran
J. Am. Chem. Soc. 2021, 143, 7859
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Among the most read articles in JACS in May 2021.
(24) Nickel-catalyzed decarbonylative amination of carboxylic acid esters
Christian A. Malapit,* Margarida Borrell,* Michael W. Milbauer, Conor E. Brigham, and Melanie S. Sanford (*equal contribution)
J. Am. Chem. Soc. 2020, 142, 5918–5923.
[paper] | [supporting information]
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Highlighted in Lautens, M.; Larin, E. M. Synfacts 2020, 15, 59. [Link]
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Highlighted in Green Chemistry Articles of Interest to Pharmaceutical Industry, OPRD 2020, 24, 2369. [Link]
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Highlighted in Items of Interest to Process R&D Chemists & Engineers, OPRD 2020, 24, 885.
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Among the most read articles in JACS in March 2020.
(23) An electrochemical reductive olefin-ketone coupling
Pengfei Hu, Byron K. Peters, Christian A. Malapit, Julien C. Vantourout, Pan Wang, Jinjun Li, Lucas Mele, Pierre-Georges Echeverria, Shelley D. Minteer, and Phil S. Baran
J. Am. Chem. Soc. 2020, 142, 20979.
[paper] | [supporting information]
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Highlighted in Davey, S. G. Nature Rev. Chem. 2021, 5, 75. [Link]
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Among the most read articles in JACS for the year 2021.
(22) Nickel-catalyzed decarbonylative synthesis of fluoroalkyl thioethers
Conor E. Brigham, Christian A. Malapit, Naish Lallo, and Melanie S. Sanford
ACS Catalysis 2020, 10, 8315–8320.
[paper] | [supporting information]
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Highlighted in Items of Interest to Process R&D Chemists & Engineers, Org. Process. Res. Dev. 2020, 24, 2369. [Link]
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Among the most read articles in ACS Catalysis in July 2020.
(21) Biphasic electrocatalytic synthesis of chiral β-hydroxy nitriles
Fangyuan Dong, Hui Chen, Christian A. Malapit, Matthew B. Prater, Min Li, Mengwei Yuan, Koun Lim, and Shelley D. Minteer
J. Am. Chem. Soc. 2020, 142, 8374.
[paper] | [supporting information]
(20) Selective electroenzymatic oxyfunctionalization by alkane monooxegenase in a biofuel cell
Mengwei Yuan, Sofiene Abdellaoui, Hui Chen, Matthew J. Kummer,
Christian A. Malapit, Chun You, and Shelley D. Minteer
Angew. Chem., Int. Ed. 2020, 59, 8969.
[paper] | [supporting information]
(19) Mechanism and scope of nickel-catalyzed decarbonylative borylation of carboxylic acid fluorides
Christian A. Malapit, James R. Bour, Simon R. Laursen, and Melanie S. Sanford
J. Am. Chem. Soc. 2019, 141, 17322–17330.
[paper] | [supporting information]
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Featured in Organic Chemistry Portal. [Link]
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Among the most read articles in JACS for 2019.
(18) Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H
Devin M. Ferguson,* Christian A. Malapit,* James R. Bour, and Melanie S. Sanford
*equal contribution
J. Org. Chem. 2019, 84, 3735–3740.
[paper] | [supporting information]
(17) Base-free nickel-catalysed decarbonylative Suzuki-Miyaura coupling of acid fluorides
Christian A. Malapit, James R. Bour, Conor E. Brigham, and Melanie S. Sanford
Nature 2018, 563, 100–104
[paper] | [supporting information]
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Highlighted in Lautens, M.; Larin, E. M. Synfacts 2019, 15, 59. [Link]
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Highlighted in ChemistryViews Magazine.
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Highlighted in Scientific Update.
(16) Palladium and nickel-catalyzed decarbonylation to convert thioesters to thioethers
Naoko Ichiishi, Christian A. Malapit, Łukasz Woźniak, and Melanie S. Sanford
Org. Lett. 2018, 20, 44–47
[paper] | [supporting information]
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Featured in Organic Chemistry Portal. [Link]
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Among the most read articles in Organic Letters for 2018.
(15) Palladium-catalyzed decarbonylative cross-couplings of aroyl chlorides
Christian A. Malapit, Naoko Ichiishi, and Melanie S. Sanford
Org. Lett. 2017, 19, 4142–4145.
[paper] | [supporting information]
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Among the most read articles in Organic Letters in July 2017.
(14) Enantioselective arylation of oxindoles using modified BI-DIME ligands
Hari P. R. Mangunuru, Christian A. Malapit, Nizar Haddad, Jonathan T. Reeves, Bo Qu, Sonia Rodriguez, Heewon Lee, Nathan K. Yee, Jinhua J. Song, Carl A. Busacca, and Chris H. Senanayake
Synthesis 2018, 50, 4435–4443
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Invited paper dedicated to Prof. Scott E. Denmark on the occasion of his 65th birthday. [Link]
(13) Rhodium-catalyzed addition of aryl boronic acids to 2,2-disubstituted malononitriles
Christian A. Malapit, Donald R. Caldwell, Irungu K. Luvaga, Jonathan T. Reeves, Ivan Volchkov, Nina C. Gonnella, Zhengxu S. Han, Carl A. Busacca,
Amy R. Howell, and Chris H. Senanayake
Angew. Chem. Int. Ed. 2017, 56, 6999–7002.
[paper] | [supporting information]
(12) Palladium-catalyzed acyl C–O bond activation for selective opening of α-methylene-β-lactones with amines
Christian A. Malapit, Donald R. Caldwell, Nicole Sassu, Samuel Milbin,
and Amy R. Howell
Org. Lett. 2017, 19, 1966–1969.
[paper] | [supporting information]
(11) Rhodium-catalyzed conjugate addition of aryl and alkenyl boronic acids to α-methylene-β-lactones: efficient, stereoselective synthesis of trans-3,4-disubstituted β-lactones
Christian A. Malapit, Irungu K. Luvaga, Donald R. Caldwell,
Nicholas K. Schipper, and Amy R. Howell
Org. Lett. 2017, 19, 4460–4463.
[paper] | [supporting information]
(10) 1,4-Dicarbofunctionalization of 4-fluoroaryl Grignard and lithium reagents with disubstituted malononitriles
Christian A. Malapit, Irungu K. Luvaga, Jonathan T. Reeves, Ivan Volchkov,
Carl A. Busacca, Amy R. Howell, and Chris H. Senanayake
J. Org. Chem. 2017, 82, 4993–4997.
[paper] | [supporting information]
(9) Development of dieldrin, endosulfan, and hexachlorobenzene-imprinted polymers for array sensing
Ofelia V. Silverio, Regina C. So, Katrina Jean S. Elnar, Christian A. Malapit,
J. Apply. Polym. Sci. 2017, 134, 44401.
[paper] | [supporting information]
(8) Rh-catalyzed transnitrilation of aryl boronic acids with dimethylmalononitrile
Christian A. Malapit, Jonathan T. Reeves, Carl A. Busacca,
Amy R. Howell, Chris H. Senanayake
Angew. Chem. Int. Ed. 2016, 55, 326
[paper] | [supporting information]
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Selected as a Hot Paper by Editors.
(7) Transnitrilation from dimethylmalononitrile to aryl Grignard and lithium reagents:
a practical method for aryl nitrile synthesis
Jonathan T. Reeves, Christian A. Malapit, Frederic G. Buono, Kanwar P. Sidhu, Maurice A. Marsini, C. Avery Sader, Keith R. Fandrick, Carl A. Busacca, and Chris H. Senanayake
- Highlighted and selected as “Synfact of the month” of October 2015; Knochel, P.; Haas, D. Synfacts 2015, 11, 1081.
- Featured in Organic Chemistry Portal. [Link]
- Among the most read articles in JACS for 2015.
(6) Nickel- or cobalt-catalyzed cross-coupling of aryl sulfonic acid salts with Grignard reagents
Christian A. Malapit, Michael D. Visco, Jonathan T. Reeves, Carl A. Busacca,
Amy R. Howell, and Chris H. Senanayake
Adv. Synth. Catal. 2015, 357, 2199–2204.
[paper] | [supporting information]
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Invited paper published in a special issue dedicated to Prof. Stephen Buchwald on his 60th birthday. [Link]
(5) Recent applications of oxetanes in the synthesis of heterocyclic compounds
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Invited JOC Synopsis article.
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Most read article in JOC in August 2015.
(4) Pt-catalyzed rearrangement of oxaspirohexanes to 3-methylenetetrahydrofurans: scope and mechanism
Christian A. Malapit, Sampada M. Chitale, Meena S. Thakur, Rosa Taboada, Amy R. Howell
J. Org. Chem. 2015, 80, 5196–5209
[paper] | [supporting information]
(3) A Roadmap for the development of nanotechnology in the Philippines
Fabian M. Dayrit, Christina C. Binag, Christian A. Malapit
A Roadmap for the development of nanotechnology in the Philippines, Chapter 5: Applications of Nanotechnology to the Environment. January 2010.
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Highlighted in Dayrit, F. M. Tech. Monitor 2010, 27, 30. [Link]
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Featured in American Ceramic Society [Link], Nanowerk News [Link], and DOST.gov [Link].
(2) Recognition properties of artemisinin-imprinted polymer microspheres
Christian A. Malapit, Kendricks S. Lao, Clovia Holdsworth, Regina C. So
[paper] | [journal cover]
(1) Evaluation of silica sol-gel encapsulation for the controlled release of N,N-diethyl-2-methoxybenzamide
Ann S. Chan, Judy del Valle, Kendricks S. Lao, Christian A. Malapit, Modesto Chua, Regina C. So
Phil. J. Science 2009, 138, 13–21.
[paper] | [supporting information]
